This is a loaded question. There are endless variables - but I’ve built more than forty indoor / greenhouse / outdoor facilities and I can partially answer.
Lets assume you’re referring to 22,000 square feet of canopy and not a 22,000 square foot space.
If growing in a warehouse
With proper HVAC and humidity control
With artificial lighting at 24 square foot layout for each 1000w lighting source
Given 30% for vegetative growth, 70% for flowering space:
Gives 14,520 square feet of flowering canopy / 24 sq feet per light = 605 lights in flower
The gold standard is for 2lbs of dried bud per light, however with proper nutrients and good genetics I regularly see 2.5lbs of dried bud per light.
605 Lights if harvested at once would be 1210lbs ~ 1512lbs - however you couldn’t harvest this all at once as your veg canopy size is too small to propagate your entire flower area so one would typically propagate 25% of their flower room per two weeks and harvest 25% of their flower room every two weeks.
For a continual harvest cycle one would assume half of the previously mentioned yields per month (605lbs ~ 756lbs).
Total number of plants using this method would be be dependent on strains of course, but an average would be between 4 and 8 plants per light at 24sq feet.
If you’re growing outdoors:
With the sun as your light source in an arid climate
Given 100% of your canopy space for flowering space
One can assume plants to be between 5 ~ 8 feet in diameter or 19.6 ~ 50 square feet in canopy for each plant. If the plants have an abundance of good nutrients, good soil, room for roots, properly pH water, and good sun AND your weather holds out for at least 65 days after the daylight drops below 14.5 hrs per day without freezing and too much rain then…perhaps you can see a yield of the radius of the plant in pounds. Example, 6 foot diameter plant, 3′ radius, 3lbs of dried bud.
There are many other factors to consider in both of these situations, however, I give advice to people who are looking to grow cannabis professionally in legal states. We are happy to answer questions and give our best advice to anyone who inquires.